2x1080Ti & i9 cpu... that's one hell of setup you've got cooking there... wowser. Well, on most motherboards you have two slots that are going to be dedicated for SLI and those are the ones you'll want to use. Typically there will be one slot of space in between the GPU's and as you already know that's a good thing for air circulation. So you don't want to block that space unless you're doing some serious custom loop water cooling. Also - if you're using those two SLI graphic card slots there will typically be a SLI bridge included in the package from your motherboard supplier that fits and the spacing won't be a problem. Is there a problem? It shoudn't be... the SLI bridge from your motherboard manufacturer should fit. Then the Lynx card is only 1x so that can be placed either above or below the graphics cards, but I'm betting above might be your best option. The 4x SSD card is the tricky one. Have you looked in your motherboard manual to check how many lanes are available when using both SLI spots? Cause that is the deal breaker. You need to find some option where you have 2x8 lanes for you gpu cards and also 4x for your SSD card. It varies a bit from motherboard to motherboard, is that in your manual somewhere? There are also PCI extension kits: https://www.google.se/search?client...1c.1.64.psy-ab..0.2.83...0i30k1.0.X42FGaAb6Y0 That can be an option if you're really tight on space and want to improve air circulation. The two SLI cards shouldn't be problem. The problem might be how to retain PCI lanes and air circulation while installing both an audio card and an SSD card.